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Amiodarone, a drug long used for treating irregular heart rhythms, can also be effective against Chagas disease and leishmaniasis skin lesions, according to Alberto Paniz-Mondolfi at Columbia University in New York, N.Y., and his collaborators in Venezuela.
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Phosphate shortages could explain how Pseudomonas aeruginosa shifts from being a mere colonizer of the human gastrointestinal (GI) tract into a lethal agent, says John Alverdy, a surgeon at the University of Chicago School of Medicine in Chicago, Ill.
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"The earth is responding to escalating carbon dioxide levels with rising seas, flooding, droughts, forest fires, and a corresponding surge in infectious disease- some all too familiar; others new," says Timothy Ford from the University of New England in Biddeford, Maine.
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If the Viking labeled-release experiment on Mars in 1976 had tested glucose optical isomers separately, it might have avoided lingering doubts about its apparently positive results suggesting biological activity, say microbiologist Henry J. Sun of the Desert Research Institute in Las Vegas, Nev., and his collaborators.
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With concerns about global warming and rising oil prices, there is renewed impetus behind efforts to harness microorganisms as a way of reducing worldwide reliance on fossil fuels.
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Very different kinds of pathogen-in this case, one a virus, the other a mycoplasma- can act as if cooperating when infecting cultured cells, with one augmenting the potency of the other, according to Peter Lidsky and Vadim I. Agol of the Russian Academy of Medical Sciences, Moscow, Russia, and their collaborators at the Academy and the nearby M. V. Lomonosov Moscow State University, as well as at Radboud University Nijmegen Medical Centre in Nijmegen, the Netherlands.
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