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In the early years of molecular biology, once it became known that DNA was the hereditary material and that DNA encoded information exactly specifying protein sequences, a number of coding schemes were proposed to explain how various combinations of the four unique bases of DNA might specify particular amino acids.
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I followed with great interest the discussion about descriptive versus hypothesisdriven research (A. Casadevall and F. C. Fang, Microbe, December 2008, p. 552- 553, andMay2009, p. 207; J. L. Slonczewski and E. S. Kaneshiro, Microbe, February 2009, p. 50).
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