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Antibiotic resistance sometimes develops in great leaps, with a recent example being the New Delhi metallo (NDM-1) β-lactamase-containing plasmid that some experts consider particularly dangerous because it is pan-resistant and "promiscuous" as it moves among commonplace pathogens.
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Analytic methods such as mass spectrometry (MS) and PCR are "challenging what we know as the gold standard" for identifying microbial pathogens, says Donna Wolk of the University of Arizona in Tucson, who spoke during the symposium, "Is the Era of Bacterial Culture Ending?" held as part of the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), in Boston, Mass., last September.
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Imaging mass spectrometry (IMS) is being harnessed to identify and map how molecules influence bacteria at the cellular level, according to Pieter Dorrestein of the Skaggs School of Pharmacy at the University of California, San Diego (UCSD) and his collaborators.
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One major component of the ambitious United Nations (UN) Millennium Development Goals (MDGs), set a decade ago, is to expand global vaccine use while reducing health and financial burdens from vaccine-preventable diseases.
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The pandemic H1N1 influenza virus, which raised alarms when it emerged in April 2009, will continue to circulate or might disappear, according to Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health in Bethesda, Md., and his collaborators.
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Microorganisms such as Deinococcus radiodurans depend on the antioxidant effects of divalent manganese [Mn(II)] complexes to survive ionizing and ultraviolet radiation, thus avoiding "death by protein damage," according to Michael J. Daly of the Uniformed Services University of the Health Sciences in Bethesda, Md., and his collaborators.
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